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Deletions of gria1 or gria2 genes encoding alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic-acid-receptor subunits differ in their effects on appetitive conditioning. The authors investigated whether similar differences would occur in an aversive conditioning test. The ability of a discrete stimulus paired with footshock to subsequently inhibit food-maintained operant responding (conditioned emotional response) was examined in mice with deletions of gria1 or gria2 genes. Whereas gria1 knockout (KO) mice performed normally compared with wild-type (WT) controls, gria2 KO mice displayed no reduction in response rates when the shock-paired stimulus was presented. Nevertheless, gria2 KOs displayed evidence of freezing in a footshock-paired context, indicating that aversive learning could occur. In addition, gria1 KO mice showed some evidence of increased anxiety, and gria2 KOs showed reduced anxiety, in the elevated plus-maze.

Original publication

DOI

10.1037/0735-7044.120.2.241

Type

Journal article

Journal

Behav Neurosci

Publication Date

04/2006

Volume

120

Pages

241 - 248

Keywords

Affective Symptoms, Analysis of Variance, Animals, Avoidance Learning, Behavior, Animal, Conditioning, Operant, Freezing Reaction, Cataleptic, In Vitro Techniques, Male, Maze Learning, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, AMPA