The ARCHIE Study: The early use of Antibiotics for 'at Risk' CHildren with InfluEnza
Flu is a viral infection which usually causes mild symptoms like cough and fever. Children with underlying conditions who develop flu, are at greater ‘at risk’ of becoming unwell from further infections than otherwise healthy children. The ARCHIE Programme will investigate five aspects of the early use of antibiotics in 'at risk' children with flu.
The ARCHIE study will help us find out whether giving ‘at risk’ children antibiotics within the first 5 days of developing flu will reduce the chances of them becoming more unwell or developing further infections. The ARCHIE study will also help us find out which children are most likely to benefit from antibiotics.
We hope to get 650 children to take part in our study.
We have GP surgeries and Hospital Trusts around England participating in the ARCHIE Study. Please find your local participating site using our map below.
We will follow up some ARCHIE study participants for up to a year to find out whether antibiotics would be effective at treating similar infections in future.
The ARCHIE study is funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (Grant Reference RP-PG-1210-12012).
Open for recruitment
Contact a participating hospital or GP surgery:
Find a participating centre near you:
If your GP surgery, clinic or local hospital is taking part please let them know you would be interested in the ARCHIE study, should your child get flu.
GP surgeries and local hospitals taking part in the ARCHIE Study:
(Red pins - GP surgeries; Blue pins - Hospitals and A&E departments; Yellow pins - Walk-in Centres.)
Click on the pin to show the name and postcode.
If your local hospital or GP surgery is listed, you can either:
- Contact our friendly study team who will be able to point you in the right direction: firstname.lastname@example.org
- Contact your local hospital - find their contact details here.
- Phone your GP surgery directly, mentioning you are interested in signing up to the Archie Study.
What do we mean by 'at risk' children?
To find out which children with flu are ‘at risk’ of becoming more unwell, we have looked at research studies on conditions which make children more likely to need treatment in hospital if they get flu. The figure below shows the results of our research on medical conditions that increase the risk of complications if children get affected by flu or flu-like illness.
How much money could we save parents and the NHS?
We will ask parents and children who take part in the ARCHIE study to tell us how having flu affects their quality-of-life and day-to-day activities (e.g. work and school). We will use this information to help us work out whether giving ‘at risk’ children antibiotics early during a flu-like illness might save the amount of money parents and the NHS have to spend when ‘at risk’ children get flu.
Activities and resources
Healthtalk.org - people's experiences of flu or flu-like illness in chronically ill or disabled children
See and hear parents sharing their personal stories on film of dealing with flu or flu-like illness in children with chronic illness or a disability.Visit healthtalk.org